Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.

Abstract

OBJECTIVE:

To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy.

DESIGN:

Case series.

SETTING:

Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

PATIENTS:

We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome.

MAIN OUTCOME MEASURES:

Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells.

RESULTS:

Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form.

CONCLUSION:

A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.

• Authors: Shigeaki Suzuki, Yukiko K Hayashi, Masataka Kuwana, Rie Tsuburaya, Norihiro Suzuki, Ichizo Nishino
• Journal: Archives of neurology (Arch Neurol) Vol. 69 Issue 6 Pg. 728-32 (Jun 2012) ISSN: 1538-3687 [Electronic] United States
• PMID: 22332183 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Anti-Inflammatory Agents
• Autoantibodies
• Signal Recognition Particle
• Prednisolone
• Creatine Kinase

Topics

• Adolescent
• Adult
• Age of Onset
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents (therapeutic use)
• Autoantibodies (blood)
• Creatine Kinase (blood)
• Disease Progression
• Female
• Humans
• Immunoprecipitation
• Male
• Middle Aged
• Muscular Diseases (blood, complications, drug therapy, immunology)
• Nervous System Diseases (etiology)
• Prednisolone (therapeutic use)
• Severity of Illness Index
• Signal Recognition Particle (immunology)
• Young Adult