Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer.

Abstract	Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.
Authors	Christian Geis, Benedikt Grünewald, Andreas Weishaupt, Thomas Wultsch, Klaus V Toyka, Andreas Reif, Claudia Sommer
Journal	Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 119 Issue 8 Pg. 981-5 (Aug 2012) ISSN: 1435-1463 [Electronic] Austria
PMID	22331304 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Autoantibodies Autoantigens Immunoglobulin G Nerve Tissue Proteins amphiphysin
Topics	Animals Anxiety (immunology) Autoantibodies (administration & dosage) Autoantigens (immunology) Behavior, Animal Disease Models, Animal Female Humans Immunoglobulin G (administration & dosage) Immunohistochemistry Injections, Spinal Nerve Tissue Proteins (deficiency, immunology) Rats Rats, Inbred Lew Stiff-Person Syndrome (immunology, psychology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!