Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles.

Abstract

Privileged structures like Benzothiazole and Pyrrolobenzodiazepine offer wonderful opportunity to explore in anti-cancer drug discovery as a mean to counter drug-resistance problem. BT-PBD hybrids and diverse BT derivatives have been synthesized and their in vitro cytotoxic activities were screened against five cancer cell lines have been discussed. The novel compounds showed promising results as compared with the marketed drug etoposide and could well be used in future anti-cancer drug development studies.

• Authors: D Subhas Bose, Mohd Idrees, Ismail K Todewale, N M Jakka, J Venkateswara Rao
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 50 Pg. 27-38 (Apr 2012) ISSN: 1768-3254 [Electronic] France
• PMID: 22325897 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Antineoplastic Agents, Phytogenic
• Benzothiazoles
• Benzodiazepines
• Etoposide
• benzothiazole

Topics

• Antineoplastic Agents (chemical synthesis, chemistry)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Benzodiazepines (chemistry)
• Benzothiazoles (chemical synthesis, chemistry)
• Etoposide (pharmacology)
• Humans
• Molecular Structure
• Neoplasms (drug therapy)
• Structure-Activity Relationship
• Tumor Cells, Cultured