Abstract | BACKGROUND: STUDY DESIGN: A double-blinded randomized controlled trial was conducted in Assiut, Egypt. DMPA users with current bleeding episode were counseled to participate. Women who agreed to participate were randomly assigned to receive 100 mg DOX twice daily for 5 days (34 patients) or an identical placebo (34 patients). All participants were asked to report bleeding and spotting days in a menstrual diary. All participants were followed for 3 months after treatment. This trial was registered (NCT01254799). RESULTS: The relative risk to stop a bleeding episode within 10 days of starting treatment was 0.88 (confidence interval 0.64-1.21) in the treatment group compared to the control. DOX treatment caused no significant difference compared to placebo in the number of bleeding and/or spotting days in the 3 months following the treatment. CONCLUSION:
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Authors | Hany Abdel-Aleem, Omar M Shaaban, Mahmoud A Abdel-Aleem, Gihan N Fetih |
Journal | Contraception
(Contraception)
Vol. 86
Issue 3
Pg. 224-30
(Sep 2012)
ISSN: 1879-0518 [Electronic] United States |
PMID | 22325113
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Contraceptive Agents, Female
- Delayed-Action Preparations
- Matrix Metalloproteinase Inhibitors
- Medroxyprogesterone Acetate
- Doxycycline
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Topics |
- Adult
- Contraceptive Agents, Female
(adverse effects)
- Delayed-Action Preparations
- Double-Blind Method
- Doxycycline
(therapeutic use)
- Female
- Humans
- Matrix Metalloproteinase Inhibitors
(therapeutic use)
- Medroxyprogesterone Acetate
(adverse effects)
- Metrorrhagia
(chemically induced, drug therapy)
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