Clinical significance of mTOR and p-mTOR protein expression in human colorectal carcinomas.

Abstract

AIM:

To investigate the significance of mammalian target of rapamycin (mTOR) and its active form, p-mTOR in colorectal carcinomas.

METHODS:

Immunohistochemistry was used to detect the expression of mTOR and p-mTOR proteins in 108, 40 and 40 tissue samples from colorectal carcinoma, normal colonic mucosa and adenomatous polyps samples, respectively. The correlation of mTOR and p-mTOR expression with clinicopathological characteristics of colorectal carcinoma was analyzed.

RESULTS:

The positive rates of mTOR and p-mTOR were significantly higher in colorectal carcinoma (61.1% and 61.1%, respectively, p<0.05) than in normal colonic mucosa (7.5% and 2.5%) and adenomatous polyps (27.5% and 20%). Overexpression of total mTOR protein was significantly associated with T1/T2 stage tumors, lymph node metastasis, distal metastasis) and degree of differentiation. p-mTOR overexpression was additionaly linked with degree of differentiation and TNM stage.

CONCLUSION:

The overexpression of mTOR and p-mTOR may play important roles in colorectal carcinogenesis with relations to the degree of differentiation, invasiveness and metastasis.

• Authors: Di Wang, Jian Chen, Fengjie Guo, Hui Chen, Zhi Duan, Mei-Yan Wei, Qi-Mei Xu, Liang-Hua Wang, Mei-Zuo Zhong
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 12 Issue 10 Pg. 2581-4 ( 2011) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22320958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MTOR protein, human
• TOR Serine-Threonine Kinases

Topics

• Adenomatous Polyps (metabolism)
• Adult
• Aged
• Aged, 80 and over
• Colorectal Neoplasms (genetics, metabolism)
• Female
• Humans
• Intestinal Mucosa (metabolism, pathology)
• Lymphatic Metastasis (pathology)
• Male
• Middle Aged
• Neoplasm Staging
• TOR Serine-Threonine Kinases (metabolism)