HLA-B*07 is a high risk allele for familial cervical cancer.

Abstract

AIM:

The purpose of this study was to investigate 50 women from eight families with familial cervical cancer in Wufeng County, Hubei Province, China, a region with a high incidence of cervical cancer. Eighty-nine healthy women, of similar age, location and ethnicity, were selected as a control group.

METHODS:

Blood samples were collected from both groups, and HLA-A, HLA-B, and HLA-DRB1 genotypes were profiled with the Multi-Analyte Profiling system (xMAP) (Luminex HLA-SSO) using a WAKFlow HLA typing kit. Results were analyzed with Luminex HLA typing software and showed good stability, reproducibility and specificity.

RESULTS:

We found several high risk alleles in women with familial cervical cancer, that associated with the highest risk being HLA-B*07 (OR = 8.7, 95% CI = 1.8-41.1).

CONCLUSIONS:

HLA-B*07 is a high risk allele for cervical cancer, and has strong potential for use as a molecular biomarker.

• Authors: Xiaoping Qiu, Fan Zhang, Dangxiao Chen, Abul Kalam Azad, Li Zhang, Yulin Yuan, Zhongqing Jiang, Wenhui Liu, Yun Tan, Ning Tao
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 12 Issue 10 Pg. 2597-600 ( 2011) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22320938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• HLA-B*07 antigen
• HLA-B7 Antigen
• Histocompatibility Antigens Class II

Topics

• Adult
• Alleles
• Biomarkers, Tumor
• Case-Control Studies
• China (epidemiology)
• Female
• Gene Frequency
• Genes, MHC Class I
• Genetic Predisposition to Disease
• Genotype
• HLA-B7 Antigen (genetics)
• Haplotypes
• Histocompatibility Antigens Class II (genetics)
• Humans
• Middle Aged
• Risk Factors
• Surveys and Questionnaires
• Uterine Cervical Neoplasms (epidemiology, genetics)
• Young Adult