Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode.

Abstract

BACKGROUND:

Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF.

METHOD:

In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI.

RESULTS:

Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage.

CONCLUSIONS:

The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.

• Authors: Qiong-Lin Liang, Xiao-Ping Liang, Yi-Ming Wang, Yuan-Yuan Xie, Rong-Li Zhang, Xi Chen, Rong Gao, Yi-Jun Cheng, Jun Wu, Qing-Bo Xu, Qing-Zhong Xiao, Xue Li, Shu-Feng Lv, Xue-Mei Fan, Hong-Yang Zhang, Qing-Li Zhang, Guo-An Luo
• Journal: Journal of translational medicine (J Transl Med) Vol. 10 Pg. 26 (Feb 08 2012) ISSN: 1479-5876 [Electronic] England
• PMID: 22316391 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Fatty Acids, Nonesterified
• NSLF6 formula
• shuanglong
• Hydrogen Peroxide
• L-Lactate Dehydrogenase
• Creatine Kinase
• Isoproterenol

Topics

• Animals
• Cell Membrane Permeability (drug effects)
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Creatine Kinase (blood)
• Discriminant Analysis
• Drug Evaluation, Preclinical (methods)
• Drugs, Chinese Herbal (administration & dosage, chemistry, pharmacology, therapeutic use)
• Fatty Acids, Nonesterified (blood)
• Human Umbilical Vein Endothelial Cells (cytology, drug effects)
• Humans
• Hydrogen Peroxide (pharmacology)
• Isoproterenol
• L-Lactate Dehydrogenase (blood)
• Myocardial Infarction (blood, drug therapy, enzymology, urine)
• Myocytes, Cardiac (drug effects, pathology)
• Neovascularization, Physiologic (drug effects)
• Oxidative Stress (drug effects)
• Principal Component Analysis
• Protein Interaction Maps
• Rats
• Reproducibility of Results
• Systems Biology