Pesticide-induced scleroderma and early intensive immunosuppressive treatment.

Abstract

The authors report 2 children with generalized cutaneous sclerosis exposed to pesticides containing malathion and diniconazole. Treatment with immunosuppressives resulted in partial improvement in the cutaneous signs, particularly over the face, trunk, and proximal limbs. The considerable exposure to chemicals related with the initiation of symptoms and absence of organ involvement suggested a diagnosis of chemically induced scleroderma-like disorder. Although autoantibodies were negative, previously reported relevant associations of anti-kinetochore and anti-topoisomerase function of active ingredients-diniconazole and phosphorodithioate-and solvents of these pesticides are also discussed. Careful follow-up for systemic involvement is warranted, since these agents may have triggered systemic scleroderma in these patients. Elimination of chemical exposure of children is stressed.

• Authors: Betul Sozeri, Nesrin Gulez, Guzide Aksu, Necil Kutukculer, Taner Akalın, Gulsen Kandiloglu
• Journal: Archives of environmental & occupational health (Arch Environ Occup Health) Vol. 67 Issue 1 Pg. 43-7 ( 2012) ISSN: 2154-4700 [Electronic] United States
• PMID: 22315935 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Pesticides
• Triazoles
• Malathion
• diniconazole

Topics

• Adolescent
• Child
• Diagnosis, Differential
• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Malathion (adverse effects)
• Male
• Pesticides (adverse effects)
• Scleroderma, Localized (chemically induced, diagnosis, drug therapy)
• Scleroderma, Systemic (diagnosis)
• Triazoles (adverse effects)