Feline panleukopenia virus, feline herpesvirus-1 and feline calicivirus antibody responses in seronegative specific pathogen-free kittens after parenteral administration of an inactivated FVRCP vaccine or a modified live FVRCP vaccine.

Two groups of feline panleukopenia (FPV), feline calicivirus (FCV) and feline herpesvirus 1 (FHV-1) seronegative kittens (six cats per group) were administered one of two feline viral rhinotracheitis, calcivirus and panleukopenia (FVRCP) vaccines subcutaneously (one inactivated and one modified live) and the serological responses to each agent were followed over 49 days (days 0, 2, 5, 7, 10, 14, 21, 28, 35, 42, 49). While the kittens administered the modified live FPV vaccine were more likely to seroconvert on day 7 after the first inoculation than kittens administered the inactivated vaccine, all kittens had seroconverted by day 14. In contrast, FHV-1 serological responses were more rapid following administration of the inactivated FVRCP vaccine when compared with the modified live FVRCP vaccine. There were no statistical differences between the serological response rates between the two FVRCP vaccines in regard to FCV.
AuthorsMichael R Lappin
JournalJournal of feline medicine and surgery (J Feline Med Surg) Vol. 14 Issue 2 Pg. 161-4 (Feb 2012) ISSN: 1532-2750 [Electronic] England
PMID22314095 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Vaccines, Attenuated
  • Vaccines, Combined
  • Vaccines, Inactivated
  • Viral Vaccines
  • Animals
  • Animals, Newborn
  • Antibodies, Viral (biosynthesis, blood)
  • Caliciviridae Infections (prevention & control, veterinary)
  • Calicivirus, Feline (immunology)
  • Cat Diseases (prevention & control, virology)
  • Cats
  • Feline Panleukopenia (prevention & control)
  • Feline Panleukopenia Virus (immunology)
  • Female
  • Herpesviridae (immunology)
  • Herpesviridae Infections (prevention & control, veterinary)
  • Male
  • Specific Pathogen-Free Organisms
  • Vaccination (veterinary)
  • Vaccines, Attenuated (administration & dosage, immunology)
  • Vaccines, Combined
  • Vaccines, Inactivated (administration & dosage, immunology)
  • Viral Vaccines (administration & dosage, immunology)

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