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Synthesis and antitumor activities of platinum complexes of unsymmetrical alicyclic diamines as carrier ligands.

Abstract
The synthesis and biological activities of the platinum complexes of 2-aminomethylaziridine, 2-aminomethylazetidine, 2-aminomethylpyrrolidine, 2-aminomethylpiperidine as carrier ligands are described. The platinum complexes of 2-aminomethylazetidine and 2-aminomethylpyrrolidine are significantly effective against murine tumors. In particular, 2-aminomethylazetidine (1,1-cyclobutanedicarboxylato)platinum II (13) and 2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platin um II (16) exhibited potent antitumor activity and were soluble in water, and their antitumor activities against Colon 26 carcinoma (sc-ip system) were superior to CBDCA and comparable to CDDP.
AuthorsK Morikawa, M Honda, K Endoh, T Matsumoto, K Akamatsu, H Mitsui, M Koizumi
JournalJournal of pharmaceutical sciences (J Pharm Sci) Vol. 79 Issue 8 Pg. 750-3 (Aug 1990) ISSN: 0022-3549 [Print] United States
PMID2231341 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Diamines
  • Drug Carriers
  • Ligands
  • Organoplatinum Compounds
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis)
  • Carcinoma (drug therapy)
  • Colonic Neoplasms (drug therapy)
  • Diamines (chemical synthesis, pharmacology)
  • Drug Carriers
  • Leukemia P388 (drug therapy)
  • Ligands
  • Male
  • Mice
  • Mice, Inbred Strains
  • Organoplatinum Compounds (chemical synthesis)

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