Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases.

Abstract

OBJECTIVE:

Recent genome-wide association studies have identified polymorphisms of lymphotoxin-α (LTA), galectin-2 (LGALS2), and proteasome subunit a type 6 (PSMA6) genes as genetic risk factors for myocardial infarction (MI). However, their effects on coronary atherosclerosis, an intermediate phenotype of MI, remain largely unknown.

METHODS:

We investigated the correlation between polymorphisms of the LTA, LGALS2, and PSMA6 genes and the severity of pathological coronary stenosis index (CSI) and MI in 1503 consecutive autopsy cases of Japanese elderly patients.

RESULTS:

The polymorphisms LTA rs1041981 and LGALS2 rs7291467 were associated with CSI with odds ratios of 1.54 (95% CI, 1.17-2.01; AA+CA over CC) and 1.62 (95% CI, 1.11-2.37; TT over CC+CT), respectively. PSMA6 rs1048990 was not associated with CSI. None of the SNPs was associated with MI in our sample.

CONCLUSION:

Our findings indicate that the LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of MI.

• Authors: Shinobu Ikeda, Noriko Tanaka, Tomio Arai, Kouji Chida, Masaaki Muramatsu, Motoji Sawabe
• Journal: Atherosclerosis (Atherosclerosis) Vol. 221 Issue 2 Pg. 458-60 (Apr 2012) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 22310064 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Galectin 2
• LGALS2 protein, human
• Lymphotoxin-alpha
• PSMA6 protein, human
• Proteasome Endopeptidase Complex

Topics

• Aged
• Aged, 80 and over
• Autopsy
• Chi-Square Distribution
• Coronary Artery Disease (epidemiology, genetics, pathology)
• Coronary Stenosis (epidemiology, genetics, pathology)
• Female
• Galectin 2 (genetics)
• Genetic Predisposition to Disease
• Humans
• Incidence
• Japan (epidemiology)
• Logistic Models
• Lymphotoxin-alpha (genetics)
• Male
• Multivariate Analysis
• Myocardial Infarction (epidemiology, genetics, pathology)
• Odds Ratio
• Phenotype
• Polymorphism, Single Nucleotide
• Prevalence
• Proteasome Endopeptidase Complex (genetics)
• Risk Assessment
• Risk Factors
• Severity of Illness Index