Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate.

Abstract

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m(2) body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

• Authors: Masaya Ishibashi, Taku Fujimura, Akira Hashimoto, Takahiro Haga, Kaoru Onami, Akira Tsukada, Yumi Kambayashi, Takanori Hidaka, Sadanori Furudate, Ryoko Shimada, Setsuya Aiba
• Journal: Case reports in dermatology (Case Rep Dermatol) Vol. 4 Issue 1 Pg. 5-9 (Jan 2012) ISSN: 1662-6567 [Electronic] Switzerland
• PMID: 22308113 (Publication Type: Case Reports)