Bioactive compounds from Carissa spinarum.

Abstract

In our continuing efforts to find new antiherpetic agents from plants, an extract prepared from the stems of Carissa spinarum L. was found to possess appreciable activity against herpes simplex viruses (HSV I and II). A chemical study of this plant was then initiated, and this led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds were evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects. The cardiac glycoside evomonoside was found to be the only antiherpetic principle, showing moderate activity against herpes simplex virus types I and II in the inactivation method. The lignans (-)-carinol, (-)-carissanol and (-)-nortrachelogenin exhibited cytotoxicity against breast (MCF7) and lung (A549) cancer cells. Moderate anti-DPPH free radical activity was observed for all the lignans. None of the isolates showed antibacterial activity.

• Authors: Ruchira Wangteeraprasert, Vimolmas Lipipun, Mekala Gunaratnam, Stephen Neidle, Simon Gibbons, Kittisak Likhitwitayawuid
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 26 Issue 10 Pg. 1496-9 (Oct 2012) ISSN: 1099-1573 [Electronic] England
• PMID: 22308099 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 John Wiley & Sons, Ltd.

Chemical References

• Anti-Bacterial Agents
• Antiviral Agents
• Coumarins
• Glycosides
• Lignans
• Plant Extracts

Topics

• Anti-Bacterial Agents (pharmacology)
• Antiviral Agents (isolation & purification, pharmacology)
• Apocynaceae (chemistry)
• Cell Line, Tumor
• Chemical Fractionation
• Coumarins (isolation & purification, pharmacology)
• Glycosides (isolation & purification, pharmacology)
• Humans
• Inhibitory Concentration 50
• Lignans (isolation & purification, pharmacology)
• Plant Extracts (pharmacology)
• Plant Stems (chemistry)
• Simplexvirus (drug effects)