HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lack of association between a functional genetic variant of connexin 37 and ischemic stroke in a Taiwanese population.

AbstractINTRODUCTION:
Connexin 37, encoded by the GJA4 gene, protects against atherosclerosis. A recent study reported an association between polymorphism rs1764391 at GJA4 and ischemic stroke in a Chinese population. We aimed to replicate this result.
MATERIALS AND METHODS:
A total of 958 ischemic stroke patients and 2196 controls were enrolled for the study. All participants were Chinese residing in Taiwan. Logistic regression analysis with adjustment for traditional risk factors was used to estimate the genetic effect. We also performed stratification analyses by sex and stroke subtypes. Literature reviews were conducted for available genetic association studies investigating rs1764391 and cardiovascular phenotypes.
RESULTS:
We did not find any significant association for overall stroke (p=0.87) or from any subset analyses. Eight studies addressing the associations between rs1764391 and cardiovascular phenotypes had a sample size greater than 1000. Including the present study, five out of the eight large-scale studies found no association.
CONCLUSIONS:
GJA4 polymorphism is not associated with stroke risk in the Taiwanese population.
AuthorsSuh-Hang Hank Juo, Yi-Chu Liao, Hsiu-Fen Lin, Po-Lin Chen, Wen-Yi Lin, Ruey-Tay Lin
JournalThrombosis research (Thromb Res) Vol. 129 Issue 4 Pg. e65-9 (Apr 2012) ISSN: 1879-2472 [Electronic] United States
PMID22305353 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Connexins
  • connexin 37
Topics
  • Aged
  • Brain Ischemia (epidemiology, genetics)
  • Comorbidity
  • Connexins (genetics)
  • Genetic Association Studies
  • Genetic Linkage (genetics)
  • Genetic Predisposition to Disease (epidemiology, genetics)
  • Genetic Variation (genetics)
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide (genetics)
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Stroke (epidemiology, genetics)
  • Taiwan (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: