Abstract | AIM AND OBJECTIVE: MATERIALS AND METHODS: After approval by the institutional animal ethics committee, six rats each were randomly assigned to groups, and treated with seven different GBCA. Intraperitoneal (IP) injections - proven in the animal model to be effective - were chosen to prolong the animals' exposure to the respective GBCA. GBCA doses of previous intravenous (IV) animal studies were applied. After five weeks all rats were sacrificed. Sham controls were treated with IP saline injections, employing the same regimen. RESULTS: No findings comparable with human NSF were observed in all animals after IP treatment with all seven GBCA at daily doses of 2.5 and 5.0 mmol/kg body weight (BW). No histopathological abnormalities of all examined organs were noted. Weight loss was stated in weeks three and four with GBCA injections at doses of 5.0 mmol/kg BW, but rats regained weight after cessation of GBCA treatment. CONCLUSIONS:
|
Authors | R D Langer, D E Lorke, K F Neidl van Gorkom, G Petroianu, S Azimullah, S M Nurulain, S Singh, M Fuchsjäger |
Journal | European journal of radiology
(Eur J Radiol)
Vol. 81
Issue 10
Pg. 2562-7
(Oct 2012)
ISSN: 1872-7727 [Electronic] Ireland |
PMID | 22304979
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Contrast Media
- Gadolinium
|
Topics |
- Animals
- Contrast Media
(toxicity)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Gadolinium
(toxicity)
- Humans
- Injections, Intraperitoneal
- Male
- Nephrogenic Fibrosing Dermopathy
(chemically induced, diagnosis)
- Rats
- Rats, Wistar
|