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[Efficacy of ivabradine in patients with stable angina and comorbid chronic obstructive pulmonary disease].

Abstract
We investigated impact of ivabradine on exercise capacity and quality of life in patients with stable angina and comorbid chronic obstructive pulmonary disease during treatment with -blockers. Ivabradine with -blockers reduced heart rate, increased exercise capacity and improved angina more effective than -blockers only. Quality of life associated with angina increased in patients with stage I and II chronic obstructive pulmonary disease. Addition of ivabradine to -blockers for 2 month did not produce adverse respiratory effects.
AuthorsA A Khamaeva, F I Belialov, L V Kerzina, O V Berezovskaia, E D Parshukova, G Iu Zakharova
JournalKardiologiia (Kardiologiia) Vol. 52 Issue 1 Pg. 15-9 ( 2012) ISSN: 0022-9040 [Print] Russia (Federation)
PMID22304347 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Benzazepines
  • Cyclic Nucleotide-Gated Cation Channels
  • Ivabradine
Topics
  • Adrenergic beta-Antagonists (administration & dosage, adverse effects)
  • Angina, Stable (diagnosis, drug therapy, epidemiology)
  • Anti-Arrhythmia Agents (administration & dosage, adverse effects)
  • Benzazepines (administration & dosage, adverse effects)
  • Comorbidity
  • Cyclic Nucleotide-Gated Cation Channels (antagonists & inhibitors)
  • Drug Therapy, Combination
  • Electrocardiography
  • Exercise Tolerance (drug effects)
  • Heart Rate (drug effects)
  • Humans
  • Ivabradine
  • Pulmonary Disease, Chronic Obstructive (drug therapy, epidemiology)
  • Quality of Life
  • Severity of Illness Index
  • Treatment Outcome

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