Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32.

Abstract

Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and 1D and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC₅₀ values ranging from 1.1 to 31 μM.

• Authors: Hongbo Huang, Tingting Yang, Xiangmei Ren, Jing Liu, Yongxiang Song, Aijun Sun, Junying Ma, Bo Wang, Yun Zhang, Caiguo Huang, Changsheng Zhang, Jianhua Ju
• Journal: Journal of natural products (J Nat Prod) Vol. 75 Issue 2 Pg. 202-8 (Feb 24 2012) ISSN: 1520-6025 [Electronic] United States
• PMID: 22304344 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Glycosides

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Glycosides (chemistry, isolation & purification, pharmacology)
• Humans
• Inhibitory Concentration 50
• Mice
• Oceans and Seas
• Streptomyces (chemistry)