The risk of stroke after percutaneous vertebroplasty for osteoporosis: a population-based cohort study.

Abstract

PURPOSE:

To investigate the incidence and risk of stroke after percutaneous vertebroplasty in patients with osteoporosis.

METHODS:

A group of 334 patients with osteoporosis, and who underwent percutaneous vertebroplasty during the study period, was compared to 1,655 age-, sex- and propensity score-matched patients who did not undergo vertebroplasty. All demographic covariates and co-morbidities were deliberately matched between the two groups to avoid selection bias. Every subject was followed-up for up to five years for stroke. Adjustments using a Cox regression model and Kaplan-Meier analyses were conducted.

RESULTS:

A total of 1,989 osteoporotic patients were followed up for 3,760.13 person-years. Overall, the incidence rates of any stroke, hemorrhagic stroke and ischemic stroke were 22.6, 4.2 and 19.6 per 1,000 person-years, respectively. Patients who underwent vertebroplasty were not more likely to have any stroke (crude hazard ratio = 1.13, p = 0.693), hemorrhagic stroke (HR = 2.21, p = 0.170), or ischemic stroke (HR = 0.96, p = 0.90). After adjusting for demographics, co-morbidities and medications, the vertebroplasty group had no significant difference with the comparison group in terms of any, hemorrhagic and ischemic strokes (adjusted HR = 1.22, 3.17, and 0.96, p = 0.518, 0.055, and 0.91, respectively).

CONCLUSIONS:

Osteoporotic patients who undergo percutaneous vertebroplasty are not at higher risk of any stroke in the next five years after the procedure.

• Authors: Ching-Lan Wu, Jau-Ching Wu, Wen-Cheng Huang, Hung-Ta H Wu, Hong-Jen Chiou, Laura Liu, Yu-Chun Chen, Tzeng-Ji Chen, Henrich Cheng, Cheng-Yen Chang
• Journal: PloS one (PLoS One) Vol. 7 Issue 1 Pg. e31405 ( 2012) ISSN: 1932-6203 [Electronic] United States
• PMID: 22303486 (Publication Type: Journal Article)

Topics

• Aged
• Cohort Studies
• Demography
• Female
• Humans
• Incidence
• Male
• Osteoporosis (epidemiology, surgery)
• Proportional Hazards Models
• Risk Factors
• Socioeconomic Factors
• Stroke (epidemiology, etiology)
• Taiwan (epidemiology)
• Vertebroplasty (adverse effects)