Efficacy of prophylactic single-dose therapy using fluoroquinolone for prostate brachytherapy.

Abstract

PURPOSE:

There is little definitive evidence to guide the use of prophylactic antibiotics for prostate brachytherapy. The purpose of this study is to evaluate the incidence of postimplant infections in patients who receive antimicrobial prophylaxis with pazufloxacin (PZFX).

MATERIALS AND METHODS:

A total of 84 patients who underwent prostate brachytherapy received a single intravenous dose of PZFX at 500 mg perioperatively for 1 day. No postimplant antibiotic medication was prescribed. Urinalysis, plasma white blood cell (WBC) count, and C reactive protein (CRP) levels were evaluated before the implantation, on the day after implantation, and on the 7th and 28th days after brachytherapy.

RESULTS:

None of the 84 patients (0.0%) developed a symptomatic urinary tract infection or had febrile infectious complications after brachytherapy. There were statistically significant elevations in the levels of erythrocytes, leukocytes, bacteria in urine, plasma WBC and CRP postoperatively, but these values did not exceed the normal range or were only slightly elevated on the day after brachytherapy (day 1) and on day 7. All laboratory examinations had returned to the normal range on day 28.

CONCLUSION:

Single-dose therapy with fluoroquinolone helps to prevent infections after prostate brachytherapy.

• Authors: Takeo Nomura, Kenichi Hirai, Mutsushi Yamasaki, Toru Inoue, Mika Takahashi, Takayuki Kawashima, Fuminori Sato, Hiromitsu Mimata
• Journal: Japanese journal of radiology (Jpn J Radiol) Vol. 30 Issue 4 Pg. 317-22 (May 2012) ISSN: 1867-108X [Electronic] Japan
• PMID: 22302294 (Publication Type: Journal Article)

Chemical References

• Fluoroquinolones
• Oxazines
• pazufloxacin

Topics

• Aged
• Antibiotic Prophylaxis
• Brachytherapy (adverse effects)
• Fluoroquinolones (administration & dosage)
• Humans
• Injections, Intravenous
• Linear Models
• Male
• Middle Aged
• Oxazines (administration & dosage)
• Prostatic Neoplasms (radiotherapy)
• Radiotherapy Dosage
• Treatment Outcome