Loss of runt-related transcription factor 3 expression associated with human hepatocellular carcinoma progression and prognosis.

Abstract

BACKGROUND:

This study aimed to evaluate the expression level of runt-related transcription factor 3 (RUNX3) in human primary hepatocellular carcinomas (HCCs) and its relationship with the clinic pathological features.

METHODS:

RUNX3 expression was analyzed by real-time fluorescent quantitative PCR, immunohistochemistry and Western blotting in HCC cells and tissues.

RESULTS:

RUNX3 RNA and protein expression was decreased in HCC tissues compared with the adjacent normal tissues (P< 0.001), mRNA frequently being down-regulated in HCC cell lines (66.67%, 4/6). Low expression of RUNX3 showed a significant correlation with cirrhosis (P = 0.028), histologic type (P = 0.000) and lymph node metastasis (P= 0.004).

CONCLUSION:

RUNX3 expression is deleted or decreased in HCCs and cell lines, in association with progression and prognosis.

• Authors: Jianguo Li, Xiaojie Jiang
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 12 Issue 9 Pg. 2285-90 ( 2011) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22296371 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Core Binding Factor Alpha 3 Subunit
• RNA, Messenger
• Runx3 protein, human

Topics

• Carcinoma, Hepatocellular (genetics, pathology)
• Cell Line
• Cell Line, Tumor
• Core Binding Factor Alpha 3 Subunit (biosynthesis, deficiency, genetics)
• Disease Progression
• Down-Regulation
• Female
• Humans
• Liver Cirrhosis (genetics)
• Liver Neoplasms (genetics, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Prognosis
• RNA, Messenger (genetics)