Association study between TRIM26 polymorphisms and risk of aspirin-exacerbated respiratory disease.

Abstract

Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome that is characterized by nasal polyposis, general symptoms of asthma and sensitive response to non-steroidal anti-inflammatory drugs (NSAIDs). Although the exact function of tripartite motif-containing 26 (TRIM26) still remains unknown, the gene functions in the immune response. Thus, we hypothesized that TRIM26 polymorphisms may affect aspirin-induced bronchospasm and explored whether the gene can be a marker for diagnosis of AERD. To investigate our hypothesis that TRIM26 may serve as a genetic marker for diagnosis of AERD, this study focused on demonstrating the associations between single nucleotide polymorphisms (SNPs) of the TRIM26 gene and AERD. We genotyped 18 polymorphisms of TRIM26 in a total of 189 asthmatics and examined their associations with the risk of AERD. We performed logistic analysis for obtaining P-values and regression analysis for demonstrating an association between the phenotype with FEV1 and the genotype. We observed no associations between polymorphisms in TRIM26 and the risk of AERD in both logistic and regression analyses. Although our results reveal a lack of association, the suggested functional role of TRIM26 makes it a putative candidate gene for AERD. Thus, replications in other populations using larger samples may provide valuable information for AERD etiology.

• Authors: Jin Sol Lee, Joon Seol Bae, Jeong-Hyun Kim, Jason Yongha Kim, Tae Joon Park, Charisse Flerida Pasaje, Byung-Lae Park, Hyun Sub Cheong, An-Soo Jang, Soo-Taek Uh, Choon-Sik Park, Hyoung Doo Shin
• Journal: International journal of molecular medicine (Int J Mol Med) Vol. 29 Issue 5 Pg. 927-33 (May 2012) ISSN: 1791-244X [Electronic] Greece
• PMID: 22294275 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA-Binding Proteins
• Tripartite Motif Proteins
• TRIM26 protein, human
• Ubiquitin-Protein Ligases

Topics

• Adolescent
• Adult
• Aged
• Asthma, Aspirin-Induced (etiology, genetics)
• DNA-Binding Proteins (genetics)
• Female
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic
• Regression Analysis
• Risk Factors
• Tripartite Motif Proteins
• Ubiquitin-Protein Ligases
• Young Adult