[Comparison of reabsorption of osmotically free water in the bud and energy of interaction of vasotocin analogs with a V2-receptor].

Abstract

The calculated values of the binding energy of nonapeptides with receptors in docking with their influence on reabsorption of osmotically free water in a rat bud in vivo were compared. Vasotocin and some its analogs were intramuscularly introduced to non-narcotized rat females of the Wistar line in doses from 0.1 pmol to 0.5 nmol/kg of body weight against the background of peroral water load (50 ml/kg of body weight). A significant correlation between the calculated interaction energy of peptides with V2-receptors and an increase of reabsorption of osmotically free water in the rat bud stimulated by injection of nonapeptides was found. The results evidence that alterations in rat bud in vivo caused by analogs of vasotocin and their interactions with V2-receptors can be accurately simulated.

• Authors: A V Kutina, T A Karavashkina, E I Shakhmatova, Ts Gao, D Iu Mordvintsev, D A Kuz'min, V I Tsetlin, Iu V Natochin
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 2011 Nov-Dec Issue 6 Pg. 717-24 ISSN: 1026-3470 [Print] Russia (Federation)
• PMID: 22292292 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Receptors, Vasopressin
• Water
• Vasotocin

Topics

• Absorption
• Animals
• Computer Simulation
• Diuresis (drug effects, physiology)
• Energy Metabolism
• Female
• Kidney (drug effects, metabolism)
• Models, Biological
• Protein Conformation
• Rats
• Rats, Wistar
• Receptors, Vasopressin (chemistry, metabolism)
• Vasotocin (analogs & derivatives, metabolism, pharmacology)
• Water (metabolism)