Abstract | OBJECTIVE: METHODS: Serum ANCA was detected in 30 children with typical Kawasaki disease (TKD) and in 16 with incomplete Kawasaki disease (IKD) in the acute and the recovery phases respectively. Twenty-five healthy children were randomly selected as a control group. An ultrasonic cardiography (UCG) was performed on children with KD in the acute phase. RESULTS: The mean positive rate of serum ANCA in the acute phase in KD children was 65%, with 69% in IKD children and 63% in TKD children, which were obviously higher than that in the control group (P<0.01). The positive rate of serum ANCA in the recovery phase in KD children was significantly lower than that in the acute phase (33% vs 65%, P<0.05). The positive rate of serum ANCA in the acute phase in children with KD was significantly higher than that detected by UCG (P<0.01). The incidence rate of coronary artery lesions in children with positive ANCA was obviously higher than that in children with negative ANCA (43% vs 13%; P<0.05). CONCLUSIONS: Serum ANCA may be used as a reference index for early diagnosis of KD and secondary coronary artery lesions in children.
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Authors | Zhi-Gui Jiang, Ling Liu, Cui-Yan Yang, Jie Wu |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 14
Issue 1
Pg. 45-7
(Jan 2012)
ISSN: 1008-8830 [Print] China |
PMID | 22289752
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
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Topics |
- Antibodies, Antineutrophil Cytoplasmic
(blood)
- Child
- Child, Preschool
- Echocardiography
- Female
- Humans
- Infant
- Male
- Mucocutaneous Lymph Node Syndrome
(blood, diagnosis)
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