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[Value of anti-neutrophil cytoplasmic antibody in diagnosis of Kawasaki disease].

AbstractOBJECTIVE:
To study the value of anti-neutrophil cytoplasmic antibody (ANCA) in diagnosis of Kawasaki disease (KD).
METHODS:
Serum ANCA was detected in 30 children with typical Kawasaki disease (TKD) and in 16 with incomplete Kawasaki disease (IKD) in the acute and the recovery phases respectively. Twenty-five healthy children were randomly selected as a control group. An ultrasonic cardiography (UCG) was performed on children with KD in the acute phase.
RESULTS:
The mean positive rate of serum ANCA in the acute phase in KD children was 65%, with 69% in IKD children and 63% in TKD children, which were obviously higher than that in the control group (P<0.01). The positive rate of serum ANCA in the recovery phase in KD children was significantly lower than that in the acute phase (33% vs 65%, P<0.05). The positive rate of serum ANCA in the acute phase in children with KD was significantly higher than that detected by UCG (P<0.01). The incidence rate of coronary artery lesions in children with positive ANCA was obviously higher than that in children with negative ANCA (43% vs 13%; P<0.05).
CONCLUSIONS:
Serum ANCA may be used as a reference index for early diagnosis of KD and secondary coronary artery lesions in children.
AuthorsZhi-Gui Jiang, Ling Liu, Cui-Yan Yang, Jie Wu
JournalZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 14 Issue 1 Pg. 45-7 (Jan 2012) ISSN: 1008-8830 [Print] China
PMID22289752 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibodies, Antineutrophil Cytoplasmic
Topics
  • Antibodies, Antineutrophil Cytoplasmic (blood)
  • Child
  • Child, Preschool
  • Echocardiography
  • Female
  • Humans
  • Infant
  • Male
  • Mucocutaneous Lymph Node Syndrome (blood, diagnosis)

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