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Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myeloma.

AuthorsJeffrey L Wolf, David Siegel, Hartmut Goldschmidt, Katharine Hazell, Priscille M Bourquelot, Bourras R Bengoudifa, Jeffrey Matous, Ravi Vij, Margarida de Magalhaes-Silverman, Rafat Abonour, Kenneth C Anderson, Sagar Lonial
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 53 Issue 9 Pg. 1820-3 (Sep 2012) ISSN: 1029-2403 [Electronic] United States
PMID22288662 (Publication Type: Clinical Trial, Phase II, Letter, Multicenter Study)
Chemical References
  • Antineoplastic Agents
  • Boronic Acids
  • Histone Deacetylase Inhibitors
  • Hydroxamic Acids
  • Indoles
  • Pyrazines
  • Thalidomide
  • Bortezomib
  • Panobinostat
  • Lenalidomide
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Area Under Curve
  • Boronic Acids (therapeutic use)
  • Bortezomib
  • Diarrhea (chemically induced)
  • Drug Administration Schedule
  • Drug Resistance, Neoplasm
  • Female
  • Histone Deacetylase Inhibitors (adverse effects, pharmacokinetics, therapeutic use)
  • Humans
  • Hydroxamic Acids (adverse effects, pharmacokinetics, therapeutic use)
  • Indoles (adverse effects, pharmacokinetics, therapeutic use)
  • Lenalidomide
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Multiple Myeloma (drug therapy, metabolism, pathology)
  • Nausea (chemically induced)
  • Neutropenia (chemically induced)
  • Panobinostat
  • Pyrazines (therapeutic use)
  • Recurrence
  • Remission Induction
  • Thalidomide (analogs & derivatives, therapeutic use)
  • Thrombocytopenia (chemically induced)
  • Treatment Outcome

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