Abstract |
Platelet monoamine oxidase activity ( MAO) in a group (n = 17) of white, female migraineurs during an acute migraine attack was similar to both the values obtained for the same group of patients two to three weeks after the headache episode ( pain-free period) and to the results obtained for a group (n = 18) of sex and race-matched, age-comparable, drug-free healthy volunteers (blind study; substrate p-tyramine, 38.7 +/- 5.7, 41.9 +/- 8.8 and 43.0 +/- 3.4 or p-methoxybenzylamine, 178.9 +/- 11.3, 177.2 +/- 6.9 and 181.0 +/- 9.7 nmole/hr/10(9) platelets +/- SD respectively). With each patient serving as its own control, MAO activity during the migraine episode and when pain-free failed to show a significant trend. Neither a number of other medical conditions nor the use of several medications appeared to significantly influence our results. The present work, while dealing only with a small but well defined patient population, argues against the possible usefulness of platelet MAO activity as a biological marker for migraine headaches.
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Authors | A D Mosnaim, S Huprikar, M E Wolf, S Diamond |
Journal | Headache
(Headache)
Vol. 30
Issue 8
Pg. 488-90
(Jul 1990)
ISSN: 0017-8748 [Print] United States |
PMID | 2228598
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Blood Platelets
(enzymology)
- Female
- Humans
- Middle Aged
- Migraine Disorders
(blood)
- Monoamine Oxidase
(blood)
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