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Platelet monoamine oxidase activity in female migraine patients.

Abstract
Platelet monoamine oxidase activity (MAO) in a group (n = 17) of white, female migraineurs during an acute migraine attack was similar to both the values obtained for the same group of patients two to three weeks after the headache episode (pain-free period) and to the results obtained for a group (n = 18) of sex and race-matched, age-comparable, drug-free healthy volunteers (blind study; substrate p-tyramine, 38.7 +/- 5.7, 41.9 +/- 8.8 and 43.0 +/- 3.4 or p-methoxybenzylamine, 178.9 +/- 11.3, 177.2 +/- 6.9 and 181.0 +/- 9.7 nmole/hr/10(9) platelets +/- SD respectively). With each patient serving as its own control, MAO activity during the migraine episode and when pain-free failed to show a significant trend. Neither a number of other medical conditions nor the use of several medications appeared to significantly influence our results. The present work, while dealing only with a small but well defined patient population, argues against the possible usefulness of platelet MAO activity as a biological marker for migraine headaches.
AuthorsA D Mosnaim, S Huprikar, M E Wolf, S Diamond
JournalHeadache (Headache) Vol. 30 Issue 8 Pg. 488-90 (Jul 1990) ISSN: 0017-8748 [Print] United States
PMID2228598 (Publication Type: Journal Article)
Chemical References
  • Monoamine Oxidase
Topics
  • Adult
  • Blood Platelets (enzymology)
  • Female
  • Humans
  • Middle Aged
  • Migraine Disorders (blood)
  • Monoamine Oxidase (blood)

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