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Coagulant and fibrinolytic activities of a metastasising and non-metastasising tumour line.

Abstract
The two types of transplantable methyl cholanthrene induced fibrosarcoma in rats was used to find out the possible relationship between the fibrinolytic, procoagulant activities and the metastasizing capacity of the tumours. The highly metastatic tumour seems to possess high fibrinolytic activity as compared to the low metastatic one. Interestingly enough, it was found that the procoagulant and fibrinolytic activities in the highly metastasising tumour bear inverse relationship with each other in relation to time of tumour growth. The procoagulant activity of the tumour bypasses factor VII and acts at factor X level. The plasminogen activator present in the tumour tissue has been characterized by sephadex G-200 column chromatography and PAGE.
AuthorsD Mohanty, P Hilgard, P Alexander
JournalIndian journal of cancer (Indian J Cancer) Vol. 27 Issue 2 Pg. 63-73 (Jun 1990) ISSN: 0019-509X [Print] India
PMID2228014 (Publication Type: Journal Article)
Chemical References
  • Methylcholanthrene
Topics
  • Animals
  • Blood Coagulation (physiology)
  • Fibrinolysis (physiology)
  • Fibrosarcoma (chemically induced, pathology, physiopathology)
  • Male
  • Methylcholanthrene
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Rats
  • Tumor Cells, Cultured

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