Body fat distribution in women with familial partial lipodystrophy caused by mutation in the lamin A/C gene.

Abstract

Familial partial lipodystrophy (FPLD), Dunnigan variety, is an autosomal dominant disorder caused due to missense mutations in the lamin A/C (LMNA) gene encoding nuclear lamina proteins. Patients with FPLD are predisposed to metabolic complications of insulin resistance such as diabetes. We sought to evaluate and compare body fat distribution with dual-emission X-ray absorptiometry in women with and without FPLD and identify densitometric, clinical and metabolic features.

• Authors: Luciana Z Monteiro, Maria C Foss-Freitas, Renan M Júnior Montenegro, Milton C Foss
• Journal: Indian journal of endocrinology and metabolism (Indian J Endocrinol Metab) Vol. 16 Issue 1 Pg. 136-8 (Jan 2012) ISSN: 2230-9500 [Electronic] India
• PMID: 22276265 (Publication Type: Case Reports)