Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles.

Abstract	In the present study, a novel poly-lactic glycolic acid (PLGA)-based microparticle formulation of perillyl alcohol (POH) was prepared and characterized. Further, its efficacy was evaluated against di-methyl benzo anthracene-induced skin papilloma in Swiss albino mice. The characterization studies showed that POH-bearing PLGA microparticles were of the size 768 ± 215 nm with a ζ-potential value of -7.56 ± 0.88 mV. The entrapment efficiency of the active drug in particles was 42.4% ± 3.5%. POH-bearing PLGA microparticles were stable and released entrapped drug gradually over an extended time period. The in vitro efficacy of POH-bearing PLGA microparticles was evaluated by examining their differential cytotoxicity and assessing their ability to inhibit epidermoid carcinoma cell line (A253). The POH-based microparticles when administered to tumor-bearing animals caused greater tumor regression and increased survival rate (∼80%) as compared with the group receiving free form of POH (survival rate 40%). The superiority of POH-PLGA microparticles over free form of POH was further evident from their ability to modulate apoptosis-regulating factors.
Authors	Mohammad Farazuddin, Bhawna Sharma, Aijaz Ahmed Khan, Beenu Joshi, Mohammad Owais
Journal	International journal of nanomedicine (Int J Nanomedicine) Vol. 7 Pg. 35-47 ( 2012) ISSN: 1178-2013 [Electronic] New Zealand
PMID	22275821 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Apoptosis Regulatory Proteins Monoterpenes Polylactic Acid-Polyglycolic Acid Copolymer Polyglycolic Acid perillyl alcohol Lactic Acid
Topics	Analysis of Variance Animals Antineoplastic Agents (chemistry, pharmacology) Apoptosis (drug effects) Apoptosis Regulatory Proteins Cell Line, Tumor Female Kaplan-Meier Estimate Lactic Acid (chemistry, pharmacology) Mice Microspheres Monoterpenes (chemistry, pharmacology) Papilloma (chemically induced, drug therapy, pathology) Polyglycolic Acid (chemistry, pharmacology) Polylactic Acid-Polyglycolic Acid Copolymer Skin Neoplasms (chemically induced, drug therapy, pathology) Xenograft Model Antitumor Assays

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