Abstract | BACKGROUND: METHODS: One-hundred and thirty-four cases of NPC with liver metastases treated with chemotherapy, chemotherapy with RFA, or RFA alone were retrospectively analyzed. Patient survival was evaluated by the log-rank test. Survival was analyses using the Kaplan-Meier method. Cox multivariate analyses of clinicopathological features and different treatment approaches were conducted. RESULTS: Local response rates were 58% in the RFA group, 78% in the chemotherapy group and 93% in the chemotherapy with RFA group (P < 0.001). Increased progression-free survival (PFS) and overall survival (OS) were observed in the chemotherapy with RFA group (P < 0.001). Cox multivariate analysis indicated that the number of liver metastases (1 vs. >1), the dimension of the largest liver metastases (≤3 cm vs. >3 cm), evaluation of treatment (response vs. no response) and disease-free survival (≤12 months vs. >12 months) were independent prognostic factors. CONCLUSIONS:
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Authors | Ying Jin, Yu-Chen Cai, Ye Cao, Xiu-Yu Cai, Yu-Ting Tan, Yan-Xia Shi, Wen-Qi Jiang |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 106
Issue 3
Pg. 322-6
(Sep 01 2012)
ISSN: 1096-9098 [Electronic] United States |
PMID | 22271524
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Wiley Periodicals, Inc. |
Chemical References |
- Paclitaxel
- Cisplatin
- Fluorouracil
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Topics |
- Carcinoma
(pathology)
- Catheter Ablation
- Chemotherapy, Adjuvant
- Cisplatin
(therapeutic use)
- Disease-Free Survival
- Female
- Fluorouracil
(therapeutic use)
- Humans
- Liver Neoplasms
(mortality, secondary, therapy)
- Male
- Middle Aged
- Multivariate Analysis
- Nasopharyngeal Neoplasms
(pathology)
- Neoplasm Recurrence, Local
- Paclitaxel
(therapeutic use)
- Prognosis
- Retrospective Studies
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