Progestin intrauterine device in an adolescent with grade 2 endometrial cancer.

Abstract

BACKGROUND:

The treatment of endometrial cancer in young women who desire future fertility poses several challenges. Oral progestin and progestin-releasing intrauterine devices (IUDs) have been shown to result in regression of endometrial hyperplasia and grade 1 endometrioid endometrial carcinoma. However, limited data are available on the use of these methods in women with grade 2 disease.

CASE:

An 18-year-old nulliparous woman was diagnosed with a grade 2 endometrial adenocarcinoma. She desired future fertility and therefore underwent placement of a levonorgestrel-releasing IUD. The patient subsequently underwent endometrial sampling every 3 months and remained disease-free 13 months after initial IUD placement.

CONCLUSION:

A progestin-releasing IUD may be a valid treatment option for grade 2 endometrial cancer in young women who desire to retain fertility.

• Authors: Alaina J Brown, Shannon N Westin, Russell R Broaddus, Kathleen Schmeler
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 119 Issue 2 Pt 2 Pg. 423-426 (Feb 2012) ISSN: 1873-233X [Electronic] United States
• PMID: 22270425 (Publication Type: Case Reports, Journal Article)

Chemical References

• Contraceptive Agents, Female
• Levonorgestrel

Topics

• Adenocarcinoma (drug therapy, surgery)
• Adolescent
• Contraceptive Agents, Female (administration & dosage)
• Endometrial Neoplasms (drug therapy, surgery)
• Female
• Fertility Preservation
• Humans
• Intrauterine Devices, Medicated
• Levonorgestrel (administration & dosage)
• Organ Sparing Treatments