Vascular endothelial growth factor and type 2 receptor for this factor in vascular malformations.

Abstract

Immunohistochemical study revealed higher level of VEGF expression in vascular malformations compared to that in normal vessels of the adjacent tissue. VEGF expression was slightly higher in the endothelium of arteriovenous angiodysplasias than in venous angiodysplasias. Enzyme immunoassay of tissue extracts showed that the concentrations of VEGF and VEGFR2 differ in arteriovenous and venous malformations. The concentrations of VEGF and VEGFR2 differed more significantly in primary and recurrent forms of arteriovenous angiodysplasias (as compared to venous angiodysplasias).

• Authors: K A Pavlov, E S Gershtein, E A Dubova, A I Shchegolev
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 150 Issue 4 Pg. 481-4 (Feb 2011) ISSN: 1573-8221 [Electronic] United States
• PMID: 22268049 (Publication Type: Journal Article)

Chemical References

• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor Receptor-2

Topics

• Adult
• Aged
• Angiodysplasia (pathology)
• Endothelium, Vascular (metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Vascular Endothelial Growth Factor A (genetics, metabolism)
• Vascular Endothelial Growth Factor Receptor-2 (genetics, metabolism)
• Vascular Malformations (metabolism)