Abstract | OBJECTIVE: METHODS: One hundred fifty-seven consecutive patients with primary squamous cell cancer of the vulva treated at our center were analyzed. All patients underwent primary surgery by triple incision resulting in complete tumor resection. RESULTS: Median age was 61 years; 49 patients (31%) had lymph node metastases; 21 patients had 1, 13 had 2, and 15 had more than 2 positive lymph nodes. Thirty-two percent of the patients received adjuvant radiotherapy. The risk of lymph node metastases increased with age, greater tumor size, deeper invasion, and higher tumor grade. Median follow-up was 36 months; 23 patients (14.6%) developed disease recurrence (61% vulva, 35% groins, and 4% both). Compared with node-negative patients, survival in all node-positive patients was significantly impaired (P < 0.001; disease-free patients after 2 years: 88% in node-negative patients; 60%, 43%, and 29% in patients with 1, 2, and >2 affected nodes, respectively), whereas no significant difference between the node-positive subgroups could be demonstrated regarding disease-free survival. In multivariate analysis, lymph node status remained the most important prognostic factor regarding disease-free survival, but the effect of positive nodes differed significantly dependent on adjuvant treatment (P = 0.001). In patients without adjuvant radiotherapy to the groins/pelvis, the number of metastatic nodes was highly relevant for prognosis (hazard ratio, 1.752; P < 0.001), whereas this effect disappeared in patients who were treated with adjuvant radiotherapy (hazard ratio, 0.972; P = 0.828). CONCLUSIONS:
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Authors | Linn Woelber, Christine Eulenburg, Matthias Choschzick, Andreas Kruell, Cordula Petersen, Friederike Gieseking, Fritz Jaenicke, Sven Mahner |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 22
Issue 3
Pg. 503-8
(Mar 2012)
ISSN: 1525-1438 [Electronic] England |
PMID | 22266935
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(diagnosis, pathology, radiotherapy, surgery)
- Cohort Studies
- Decision Making
(physiology)
- Female
- Follow-Up Studies
- Humans
- Lymph Node Excision
- Lymph Nodes
(pathology, surgery)
- Lymphatic Metastasis
- Middle Aged
- Prognosis
- Radiotherapy, Adjuvant
- Vulvar Neoplasms
(diagnosis, pathology, radiotherapy, surgery)
- Young Adult
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