Abstract |
The regional haemodynamic profiles of Ro 31-6930, cromakalim and nifedipine were compared using pulsed Doppler flowmetry in the anaesthetised rat. In order of potency, Ro 31-6930 (0.1-300 micrograms/kg), cromakalim (1-300 micrograms/kg) and nifedipine (1-1000 micrograms/kg) produced dose related falls in mean arterial pressure. The hypotensive effects of Ro 31-6930 and cromakalim were accompanied by reflex tachycardia. All three agents reduced renal vascular resistance by 30-50%. Cromakalim exerted a selective action on this vascular bed. Similar maximal reductions in mesenteric vascular resistance (37-50%) were observed; however, cromakalim was the least potent on this vascular bed. Maximal reductions in iliac vascular resistance (65-78%) were observed, with an order of potency as observed on mean arterial pressure. Qualitative differences in the regional haemodynamic profiles of Ro 31-6930, cromakalim and nifedipine are evident from this study. The different profiles of Ro 31-6930 and cromakalim may reflect structural differences between the pharmacophores of these compounds.
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Authors | S Duty, P M Paciorek, J F Waterfall, A H Weston |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 185
Issue 1
Pg. 35-42
(Aug 21 1990)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 2226633
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antihypertensive Agents
- Benzopyrans
- Pyridines
- Pyrroles
- Cromakalim
- Ro 31-6930
- Nifedipine
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Topics |
- Anesthesia
- Animals
- Antihypertensive Agents
(pharmacology)
- Benzopyrans
(pharmacology)
- Blood Pressure
(drug effects)
- Cromakalim
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects)
- Iliac Artery
(drug effects)
- Male
- Nifedipine
(pharmacology)
- Pyridines
(pharmacology)
- Pyrroles
(pharmacology)
- Rats
- Regional Blood Flow
(drug effects)
- Renal Circulation
(drug effects)
- Splanchnic Circulation
(drug effects)
- Vascular Resistance
(drug effects)
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