National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease.

Abstract

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

• Authors: Bradley T Hyman, Creighton H Phelps, Thomas G Beach, Eileen H Bigio, Nigel J Cairns, Maria C Carrillo, Dennis W Dickson, Charles Duyckaerts, Matthew P Frosch, Eliezer Masliah, Suzanne S Mirra, Peter T Nelson, Julie A Schneider, Dietmar Rudolf Thal, Bill Thies, John Q Trojanowski, Harry V Vinters, Thomas J Montine
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 8 Issue 1 Pg. 1-13 (Jan 2012) ISSN: 1552-5279 [Electronic] United States
• PMID: 22265587 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 The Alzheimer's Association. All rights reserved.

Topics

• Alzheimer Disease (diagnosis, epidemiology)
• Brain (pathology)
• Consensus Development Conferences, NIH as Topic
• Humans
• National Institute on Aging (U.S.) (standards)
• Practice Guidelines as Topic (standards)
• Societies, Medical (standards)
• United States (epidemiology)