Abstract | INTRODUCTION:
Omalizumab has been demonstrated to be a successful therapy in the management of asthma through reduction of patient's symptoms and use of inhaled corticosteroids. The effect of omalizumab is achieved by immunoglobulin E ( IgE) blockage and other secondary mechanisms resulting from this blockage. Because other diseases have an important IgE mediation in their physiopathology, the question arises as to if omalizumab would be useful in the treatment of other IgE-mediated diseases. OBJECTIVE: METHODS: We reviewed the literature using PUBMED, EMBASE, and LILACS for publications which used omalizumab in the treatment of patients with allergic diseases or any other diseases. Complete articles published in English, Spanish or Portuguese were included. CONCLUSION:
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Authors | J Sanchez, R Ramirez, S Diez, S Sus, A Echenique, M Olivares, R Cardona |
Journal | Allergologia et immunopathologia
(Allergol Immunopathol (Madr))
2012 Sep-Oct
Vol. 40
Issue 5
Pg. 306-15
ISSN: 1578-1267 [Electronic] Singapore |
PMID | 22264640
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2011 SEICAP. Published by Elsevier Espana. All rights reserved. |
Chemical References |
- Antibodies, Anti-Idiotypic
- Antibodies, Monoclonal, Humanized
- Receptors, IgE
- Omalizumab
- Immunoglobulin E
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Topics |
- Animals
- Antibodies, Anti-Idiotypic
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Asthma
(drug therapy, immunology)
- Cell Degranulation
(drug effects)
- Humans
- Hypersensitivity
(drug therapy, immunology)
- Immunoglobulin E
(immunology)
- Immunosuppression Therapy
(methods)
- Lymphocyte Activation
(drug effects)
- Omalizumab
- Receptors, IgE
(immunology)
- United States
- United States Food and Drug Administration
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