Abstract |
Marked inhibitory effects of hybrid liposomes (HL-n; n=21, 23, 25) composed of 90 mol% l-α- dimyristoylphosphatidylcholine ( DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of two human osteosarcoma cell lines (MG-63 and U-2 OS) were obtained. Furthermore, fluorescence microscopic and flow cytometric analyses revealed the induction of apoptosis by HL-n in both cells. It is noteworthy that HL-23 could inhibit the invasion and migration of U-2 OS cells on the basis of matrigel invasion assay and scratch wound assay, respectively.
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Authors | Hideki Kitajima, Yuji Komizu, Ryuichi Ueoka |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 22
Issue 4
Pg. 1784-7
(Feb 15 2012)
ISSN: 1464-3405 [Electronic] England |
PMID | 22260774
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ltd. All rights reserved. |
Chemical References |
- Liposomes
- Polyethylene Glycols
- Dimyristoylphosphatidylcholine
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Topics |
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Dimyristoylphosphatidylcholine
(chemistry, pharmacology)
- Flow Cytometry
- Humans
- Inhibitory Concentration 50
- Liposomes
(chemistry, pharmacology)
- Molecular Structure
- Neoplasm Invasiveness
- Osteosarcoma
(drug therapy)
- Polyethylene Glycols
(chemistry, pharmacology)
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