Abstract | BACKGROUND: METHODS: We systematically searched for randomized clinical trials that compared pemetrexed-based doublet with single-agent pemetrexed in patients with histologically proven non-small-cell lung cancer. The primary end point was overall survival. Secondary end points were progression-free survival, overall response rate and grade 3 or 4 toxicity. Data were extracted from the studies by 2 independent reviewers. The meta-analysis was performed by Stata version 10.0 software (Stata Corporation, College Station, Texas, USA). RESULTS: Five randomized clinical trials (totally 1,186 patients) were eligible. Meta-analysis showed that there was significant improvement in PFS (HR 0.82, 95% CI 0.71-0.95, P = 0.007) and overall response rate (OR 2.39, 95% CI 1.58-3.62, P = 0.000) in pemetrexed-based doublet group, compared with pemetrexed alone, though the pooled HR for overall survival (HR 0.89, 95% CI 0.76-1.04; P = 0.129) showed no significant difference between the two groups. However, there were more incidences of grade 3 or 4 neutropenia (OR 2.3, 95% CI 1.4-3.77, P = 0.001), thrombocytopenia (OR 6.41, 95% CI 2.57-16.0, P = 0.000), and leucopenia (OR 2.45, 95% CI 1.13-5.34, P = 0.024) in pemetrexed-based doublet group. With regard to the risk of grade 3 or 4 anemia (OR 0.71, 95% CI 0.17-2.91, P = 0.629) and fatigue (OR 1.47, 95% CI 0.92-2.35, P = 0.104), there was no significant difference between the two groups. CONCLUSION:
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Authors | Wei-Xiang Qi, Li-Na Tang, Ai-Na He, Zan Shen, Yang Yao |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 138
Issue 5
Pg. 745-51
(May 2012)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 22258853
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Glutamates
- Pemetrexed
- Guanine
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Topics |
- Algorithms
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, mortality)
- Chemotherapy, Adjuvant
- Glutamates
(administration & dosage, adverse effects)
- Guanine
(administration & dosage, adverse effects, analogs & derivatives)
- Humans
- Lung Neoplasms
(drug therapy, mortality)
- Pemetrexed
- Quality of Health Care
- Randomized Controlled Trials as Topic
(statistics & numerical data)
- Survival Analysis
- Treatment Outcome
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