aPTT prolongation and skin eruption possibly associated with lamotrigine monotherapy in a paediatric patient.

Abstract

We report the case of a six-year-old female with childhood absence epilepsy who developed combined aPTT prolongation, not corrected by normal plasma, and atypical skin eruption six months after initiating lamotrigine treatment with dose increment. Two weeks after lamotrigine withdrawal, the skin eruption disappeared and aPTT normalised. To our knowledge, this is the first report of aPTT prolongation possibly due to factor inhibitors associated with lamotrigine monotherapy.

• Authors: Jung Sook Yeom, Ji Sook Park, Ji Hyun Seo, Eun Sil Park, Jae Young Lim, Chan-Hoo Park, Hyang Ok Woo, Hee-Shang Youn
• Journal: Epileptic disorders : international epilepsy journal with videotape (Epileptic Disord) Vol. 13 Issue 4 Pg. 452-5 (Dec 2011) ISSN: 1294-9361 [Print] France
• PMID: 22258053 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Blood Coagulation Factors
• Triazines
• Lamotrigine

Topics

• Anticonvulsants (adverse effects, therapeutic use)
• Blood Chemical Analysis
• Blood Coagulation Factors (metabolism)
• Child
• Drug Eruptions (pathology)
• Electroencephalography
• Epilepsy, Absence (blood, complications, drug therapy)
• Female
• Humans
• Lamotrigine
• Partial Thromboplastin Time
• Skin (pathology)
• Triazines (adverse effects, therapeutic use)