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Splenic tuberculosis in a patient with ankylosing spondylitis treated with adalimumab.

Abstract
We present a rare case of splenic tuberculosis in a 42-year old man with long-standing ankylosing spondylitis treated with adalimumab. We review the association between antitumor necrosis factor therapy and splenic tuberculosis. Our case, like many other reported cases, illustrates that the index of suspicion of tuberculosis in patients treated with anti TNF therapies must be high and emphasizes that this rare infection may occur even with negative tuberculosis screening before the initiation of therapy.
AuthorsV F Azevedo, E Paiva, T Tosin, A Ferreira, A M Ferreira, M Fernandes
JournalReumatismo (Reumatismo) Vol. 63 Issue 3 Pg. 171-4 (Nov 09 2011) ISSN: 0048-7449 [Print] Italy
PMID22257918 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal, Humanized
  • Antirheumatic Agents
  • Immunosuppressive Agents
  • Tumor Necrosis Factor-alpha
  • Adalimumab
  • Methotrexate
Topics
  • Adalimumab
  • Adult
  • Antibodies, Monoclonal, Humanized (adverse effects)
  • Antirheumatic Agents (adverse effects)
  • Drug Therapy, Combination
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents (adverse effects)
  • Male
  • Methotrexate (therapeutic use)
  • Opportunistic Infections (diagnosis, etiology)
  • Spondylitis, Ankylosing (complications, drug therapy)
  • Tomography, X-Ray Computed
  • Tuberculosis, Pulmonary (diagnosis, etiology)
  • Tuberculosis, Splenic (diagnosis, etiology)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

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