Abstract | OBJECTIVE: METHOD: In a prospective nested case-control study, we compared the concentration of IgE, IgG, IL-4, histamine of 18 cases in anaphylaxis induced by Qingkailing injection with those from 72 matched controls who remained normal after the using Qingkailing injection. The correlation between the change of IgE, IgG, IL-4, histamine of serum and the occurrence of anaphylaxis in patients induced by Qingkailing injection was determined, and we also evaluate the clinical values of IgE, IgG, IL-4, histamine of serum in diagnosis of anaphylaxis in patients induced by Qingkailing injection by receiver operating characteristic (ROC) curves. RESULT: The concentrations of IgE, IgG, IL-4, histamine of serum of 18 cases were significantly higher than those in controls (P<0.05), the area under the curve (AUC) of IL-4, IgG, IgE, histamine were 0.362 (95.0% CI. for EXP was 0.978-2.405), 0.349 (95.0% CI. for EXP was 1.448-316.232), 0.350 (95.0% CI. for EXP was 1.262-601.306), 0.374 (95.0% CI. for EXP was 1.003-45.413), respectively. CONCLUSION:
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Authors | Yubin Zhao, Ying Xiao, Yanming Xie |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 36
Issue 18
Pg. 2579-83
(Sep 2011)
ISSN: 1001-5302 [Print] China |
PMID | 22256770
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Immunoglobulin G
- Qingkailing
- Interleukin-4
- Immunoglobulin E
- Histamine
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Topics |
- Adult
- Anaphylaxis
(chemically induced, diagnosis, immunology)
- Animals
- Case-Control Studies
- Drugs, Chinese Herbal
(administration & dosage)
- Female
- Histamine
(metabolism)
- Humans
- Immunoglobulin E
(blood, drug effects)
- Immunoglobulin G
(blood, drug effects)
- Injections
- Interleukin-4
(blood, metabolism)
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Prospective Studies
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