| Abstract | In 10 patients with chronic plaque type psoriasis one or two plaques affected equally with psoriasis were chosen for study. Five punched out rings of a hydrocolloid dressing were applied to the psoriasis plaque(s). In each circular test area 20 mg of one of the following creams was applied: base, 1% hydrocortisone (DAK), 0.1% triamcinolone acetonide (Kenalogue), 0.1% betamethasone-17-valerate cream (Betnovate), and 0.05% clobetasol proprionate cream (Dermovate). The areas were occluded with a thin film of transparent hydrocolloid dressing (Comfeel Transparent Dressing), for 1 week. Non-invasive measurements (ultrasound skin thickness, laser-Doppler flowmetry, colorimetry) were performed before and after treatment. Therapeutic response was evaluated blindly by clinical score. The measurements showed a decline in blood flow, a decrease in skin thickness, and normalization of colour approaching that of normal skin, the more potent the corticosteroid used. The clinical scores showed the same: the more potent a corticosteroid used, the closer to the score of normal skin. Data on variability and applications of the methods are presented. The study concludes that potent corticosteroids occluded with a hydrocolloid dressing can clear psoriasis in 1 week. Short-course corticosteroid therapy appears harmless and relevant for clinical dermatology. |
| Authors | U Broby-Johansen, T Karlsmark, L J Petersen, J Serup
(Affiliation: Department of Dermatology (Bioengineering and Skin Laboratory), Rigshospitalet, University of Copenhagen, Denmark.)
|
| Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 15
Issue 5
Pg. 343-8
(Sep 1990)
ISSN: 0307-6938 ENGLAND |
| PMID | 2225536
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Inflammatory Agents
- Colloids
- Glucocorticoids
- Betamethasone 17-Valerate
- Clobetasol
- Hydrocortisone
- Triamcinolone Acetonide
|
| Topics |
- Administration, Topical
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Bandages, Hydrocolloid
- Betamethasone 17-Valerate
(therapeutic use)
- Clobetasol
(analogs & derivatives, therapeutic use)
- Colloids
- Female
- Glucocorticoids
- Humans
- Hydrocortisone
- Male
- Middle Aged
- Occlusive Dressings
- Psoriasis
(drug therapy, pathology)
- Skin
(blood supply, drug effects, pathology)
- Time Factors
- Triamcinolone Acetonide
(therapeutic use)
|
