HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats.

Abstract
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean control (Ctl), obese Ctl rats had higher serum haptoglobin and impaired T-cell-stimulated cytokine responses. VA and EA diets improved T-cell-stimulated cytokine production; but, only VA normalized serum haptoglobin. However, EA- and VA-fed rats had enhanced LPS-stimulated cytokine responses. The changes elicited by VA were likely due changes in essential fatty acid composition in PL; whereas EA-induced changes may due to direct incorporation into membrane PL.
AuthorsMegan R Ruth, Ye Wang, Howe-Ming Yu, Susan Goruk, Martin J Reaney, Spencer D Proctor, Donna F Vine, Catherine J Field
JournalNutrients (Nutrients) Vol. 2 Issue 2 Pg. 181-97 (02 2010) ISSN: 2072-6643 [Electronic] Switzerland
PMID22254015 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cytokines
  • Fatty Acids
  • Haptoglobins
  • Mitogens
  • Oleic Acids
  • Phospholipids
  • Oleic Acid
  • elaidic acid
  • 11-octadecenoic acid
Topics
  • Animals
  • Case-Control Studies
  • Cytokines (biosynthesis)
  • Diet
  • Disease Models, Animal
  • Fatty Acids (metabolism)
  • Haptoglobins (metabolism)
  • Insulin Resistance
  • Mitogens (pharmacology)
  • Obesity (metabolism)
  • Oleic Acid (administration & dosage, pharmacology)
  • Oleic Acids (administration & dosage, pharmacology)
  • Phospholipids (chemistry, metabolism)
  • Rats
  • Spleen (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: