Interleukin-1ß and interleukin-1 receptor accessory protein gene polymorphisms are associated with persistent hepatitis B virus infection.

Abstract

BACKGROUND/AIMS:

The reasons for persistent HBV infection are unknown, but they are probably related to host immune factors. IL-1ß plays significant roles in inflammation and immune defense via IL-1RAcP. We investigated whether genetic polymorphisms of IL-1ß and IL-1RAcP genes are associated with persistent HBV infection and the presence of HCC.

METHODOLOGY:

We enrolled a total of 292 patients with chronic HBV infection (111 with chronic hepatitis, 95 with liver cirrhosis and 86 with HCC) and 107 healthy individuals who recovered from HBV infection. We assessed 28 SNPs in IL- 1ß and IL-1RAcP genes by using Illumina's Sentrix array matrix chip.

RESULTS:

IL-1ß-2023 C allele, IL-1RAcP -8261 T allele and -8183 A allele were significantly associated with persistent HBV infection (OR=1.63, p=0.03, OR=0.64, p<0.01 and OR=0.20, p=0.01, respectively). IL- 1ß 289 C allele was marginally associated with an increased risk for the presence of HCC (OR=1.55, p=0.04). On the haplotype analysis, IL-1ß-2023C/-581C/2893C haplotype and IL-1RAcP -8261T/-8183A haplotype were associated with persistent HBV infection. There was no significant association between the haplotypes of IL-1ß/IL-1RAcP and the presence of HCC.

CONCLUSIONS:

The genetic polymorphisms of IL-1ß-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection.

• Authors: Soon Sun Kim, Jae Youn Cheong, Dami Lee, Seung Ku Lee, Min-Ho Kim, Kyubum Kwack, Song-Ju Yang, Hyun-Young Lee, Sung Won Cho
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2012 Jan-Feb Vol. 59 Issue 113 Pg. 190-7 ISSN: 0172-6390 [Print] Greece
• PMID: 22251538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• IL1RAP protein, human
• Interleukin-1 Receptor Accessory Protein
• Interleukin-1beta

Topics

• Adult
• Asian People (genetics)
• Carcinoma, Hepatocellular (genetics, immunology, virology)
• Chi-Square Distribution
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Haplotypes
• Hepatitis B, Chronic (complications, ethnology, genetics, immunology)
• Humans
• Interleukin-1 Receptor Accessory Protein (genetics)
• Interleukin-1beta (genetics)
• Linkage Disequilibrium
• Liver Cirrhosis (genetics, immunology, virology)
• Liver Neoplasms (genetics, immunology, virology)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Oligonucleotide Array Sequence Analysis
• Phenotype
• Polymorphism, Single Nucleotide
• Republic of Korea (epidemiology)
• Risk Assessment
• Risk Factors