Association analysis of STX1A gene variants in common forms of migraine.

Abstract

OBJECTIVES:

To examine the association of genetic variants in the syntaxin 1A gene (STX1A) with common forms of migraine, and perform a combined analysis of the data from the current study and previously published reports.

METHODS:

We investigated the parent-to-offspring transmission of rs6951030, rs4363087 and rs2293489 in 191 family trios, each with a proband with childhood-onset migraine, and performed a case-control analysis between the probands and 223 unrelated controls. In addition, we performed a combined data analysis with an overall sample of 567 migraine patients and 720 unrelated controls and performed a migraine-specific gene-network analysis.

RESULTS:

The transmission disequilibrium test revealed significant transmission distortion of rs4363087 in migraine overall (OR = 1.56, p = 0.006; p = 0.01 after correction for multiple testing) and migraine without aura (OR = 1.58, p = 0.01; corrected p = 0.04). Two-marker haplotype analysis revealed transmission distortion of A-G (rs6951030-rs4363087; OR = 1.47, p = 0.01) and A-C (rs4363087-rs2293489; OR = 0.66, p = 0.01). Combined analysis showed significant association of rs941298 with migraine overall (OR = 1.28, p = 0.004) and migraine without aura (OR = 1.3, p = 0.008). Network analysis identified 24 genes relating STX1A to other migraine candidate genes, including KCNK18 (TRESK channel) involved in the cytoplasmatic calcium signalling together with syntaxin 1A.

CONCLUSION:

Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine.

• Authors: Maria Tropeano, Ciçek Wöber-Bingöl, Andreas Karwautz, Gudrun Wagner, Evangelos Vassos, Sara Campos-de-Sousa, Andrea Graggaber, Heidi E Zesch, Christian Kienbacher, Sofia Natriashvili, Incifer Kanbur, Christian Wöber, David A Collier
• Journal: Cephalalgia : an international journal of headache (Cephalalgia) Vol. 32 Issue 3 Pg. 203-12 (Feb 2012) ISSN: 1468-2982 [Electronic] England
• PMID: 22250207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• STX1A protein, human
• Syntaxin 1

Topics

• Adolescent
• Case-Control Studies
• Child
• Female
• Genetic Predisposition to Disease (genetics)
• Genetic Variation
• Genome-Wide Association Study
• Genotype
• Humans
• Male
• Migraine Disorders (genetics)
• Pedigree
• Syntaxin 1 (genetics)
• Young Adult