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Association analysis of STX1A gene variants in common forms of migraine.

AbstractOBJECTIVES:
To examine the association of genetic variants in the syntaxin 1A gene (STX1A) with common forms of migraine, and perform a combined analysis of the data from the current study and previously published reports.
METHODS:
We investigated the parent-to-offspring transmission of rs6951030, rs4363087 and rs2293489 in 191 family trios, each with a proband with childhood-onset migraine, and performed a case-control analysis between the probands and 223 unrelated controls. In addition, we performed a combined data analysis with an overall sample of 567 migraine patients and 720 unrelated controls and performed a migraine-specific gene-network analysis.
RESULTS:
The transmission disequilibrium test revealed significant transmission distortion of rs4363087 in migraine overall (OR = 1.56, p = 0.006; p = 0.01 after correction for multiple testing) and migraine without aura (OR = 1.58, p = 0.01; corrected p = 0.04). Two-marker haplotype analysis revealed transmission distortion of A-G (rs6951030-rs4363087; OR = 1.47, p = 0.01) and A-C (rs4363087-rs2293489; OR = 0.66, p = 0.01). Combined analysis showed significant association of rs941298 with migraine overall (OR = 1.28, p = 0.004) and migraine without aura (OR = 1.3, p = 0.008). Network analysis identified 24 genes relating STX1A to other migraine candidate genes, including KCNK18 (TRESK channel) involved in the cytoplasmatic calcium signalling together with syntaxin 1A.
CONCLUSION:
Our results provide support for the hypothesis that STX1A represents a susceptibility gene for migraine.
AuthorsMaria Tropeano, Ciçek Wöber-Bingöl, Andreas Karwautz, Gudrun Wagner, Evangelos Vassos, Sara Campos-de-Sousa, Andrea Graggaber, Heidi E Zesch, Christian Kienbacher, Sofia Natriashvili, Incifer Kanbur, Christian Wöber, David A Collier
JournalCephalalgia : an international journal of headache (Cephalalgia) Vol. 32 Issue 3 Pg. 203-12 (Feb 2012) ISSN: 1468-2982 [Electronic] England
PMID22250207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • STX1A protein, human
  • Syntaxin 1
Topics
  • Adolescent
  • Case-Control Studies
  • Child
  • Female
  • Genetic Predisposition to Disease (genetics)
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Migraine Disorders (genetics)
  • Pedigree
  • Syntaxin 1 (genetics)
  • Young Adult

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