Abstract | BACKGROUND: The quality of MRI and CT depends largely on immobility of the patient during the procedure, which is often difficult to achieve without sedation in children below the age of 6 years. OBJECTIVE: To assess the efficacy and safety of intravenous chlorpromazine sedation for repeated imaging in young children treated for cancer. MATERIALS AND METHODS: From July 2003 to January 2007, information on children younger than 6 years of age having MRI or CT was prospectively collected. Forty-five minutes before the scan, a 10-min infusion of chlorpromazine 0.5 mg/kg was administered and managed by non- anesthetic staff. Patient monitoring included continuous measurement of pulse, respiration, oxygen saturation and arterial blood pressure. Procedure-related parameters and adverse events were documented. Sedation was considered successful when the procedure was completed and at least 95% of images were usable. RESULTS: One-hundred-one procedures (82 MRI, 19 CT) were evaluated in 62 children, 3-74 months old. Adequate sedation was achieved in 96% of cases, with mean induction time, 22 min; mean duration of sleep, 72 min, and mean duration of procedure, 33 min. Mean time spent in the radiology unit was 104 min. Ninety-six percent of imaging procedures were successfully completed. No cardiac, respiratory, neurological or allergic complication occurred. CONCLUSION: Intravenous chlorpromazine is safe and effective for procedural sedation in young children with cancer undergoing MRI and CT.
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Authors | C Heng Vong, A Bajard, P Thiesse, E Bouffet, H Seban, P Marec Bérard |
Journal | Pediatric radiology
(Pediatr Radiol)
Vol. 42
Issue 5
Pg. 552-61
(May 2012)
ISSN: 1432-1998 [Electronic] Germany |
PMID | 22246411
(Publication Type: Journal Article)
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Chemical References |
- Anesthetics, Intravenous
- Chlorpromazine
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Topics |
- Anesthetics, Intravenous
(administration & dosage)
- Child
- Child, Preschool
- Chlorpromazine
(administration & dosage)
- Deep Sedation
(methods)
- Female
- Humans
- Infant
- Logistic Models
- Magnetic Resonance Imaging
- Male
- Monitoring, Physiologic
- Prospective Studies
- Tomography, X-Ray Computed
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