PAS kinase: integrating nutrient sensing with nutrient partitioning.

Abstract	Recent data suggests that PAS kinase acts as a signal integrator to adjust metabolic behavior in response to nutrient conditions. Specifically, PAS kinase controls the partitioning of nutrient resources between the myriad of possible fates. In this capacity, PAS kinase elicits a pro-growth program, which includes both signaling and metabolic control, both in yeast and in mammals. We propose that, like other kinases possessing these properties-AMPK and TOR, PAS kinase might be target for therapy of diabetes, obesity and cancer.
Authors	Caleb M Cardon, Jared Rutter
Journal	Seminars in cell & developmental biology (Semin Cell Dev Biol) Vol. 23 Issue 6 Pg. 626-30 (Aug 2012) ISSN: 1096-3634 [Electronic] England
PMID	22245833 (Publication Type: Journal Article, Review)
Copyright	Copyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References	PAS domain kinases Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases
Topics	Animals Humans Metabolic Diseases (metabolism) Mice Nutritional Physiological Phenomena Protein Serine-Threonine Kinases (chemistry, metabolism) Saccharomyces cerevisiae (metabolism) TOR Serine-Threonine Kinases (metabolism)

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