Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to investigate the efficacy of clopidogrel for the prevention of thromboembolic complications during elective coil embolization of unruptured cerebral aneurysms. METHODS: Sixty-three patients prospectively received oral clopidogrel 75 mg/day from 3 days before and for 1 day after the procedure at our institute (Kohnan Hospital, Sendai, Japan) during 2007. RESULTS: At 24 hours post-coiling, significantly less high-intensity areas, detected by MRI with diffusion-weighted imaging (MRI-DWI), were observed in clopidogrel-treated patients compared with a historical control cohort of aspirin ( acetylsalicylic acid)-treated patients (13/63 [20.6%] vs 27/69 [39.1%]; p = 0.02), primarily due to a statistically significantly lower rate during repair of small (<10 mm) lesions (p = 0.008). Also, the rate of periprocedural thromboembolic events was lower in the clopidogrel than the aspirin cohort (2/63 [3.2%] vs 5/69 [7.2%]; p = 0.3). CONCLUSIONS:
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Authors | Yasushi Matsumoto, Ryushi Kondo, Yasuhiko Matsumori, Hiroaki Shimizu, Akira Takahashi, Teiji Tominaga |
Journal | Drugs in R&D
(Drugs R D)
Vol. 12
Issue 1
Pg. 1-7
(Mar 01 2012)
ISSN: 1179-6901 [Electronic] New Zealand |
PMID | 22242721
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Platelet Aggregation Inhibitors
- Clopidogrel
- Ticlopidine
- Aspirin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aspirin
(administration & dosage, therapeutic use)
- Cerebral Angiography
- Clopidogrel
- Embolization, Therapeutic
(adverse effects)
- Female
- Humans
- Incidence
- Intracranial Aneurysm
(complications, diagnostic imaging, therapy)
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
(administration & dosage, therapeutic use)
- Prospective Studies
- Retrospective Studies
- Thromboembolism
(epidemiology, etiology, prevention & control)
- Ticlopidine
(administration & dosage, analogs & derivatives, therapeutic use)
- Treatment Outcome
- Young Adult
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