Abstract |
There is no current cure for Duchenne muscular dystrophy (DMD), and palliative and prophylactic interventions to improve the quality of life of patients remain limited, with the exception of corticosteroids. This article describes 2 potential nutritional interventions for the treatment of DMD, green tea extract (GTE) and the branched-chain amino acid leucine, and their positive effects on physical activity. Both GTE and leucine are suitable for human consumption, are easily tolerated with no side effects, and, with appropriate preclinical data, could be brought forward to clinical trials rapidly.
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Authors | J Davoodi, C D Markert, K A Voelker, S M Hutson, Robert W Grange |
Journal | Physical medicine and rehabilitation clinics of North America
(Phys Med Rehabil Clin N Am)
Vol. 23
Issue 1
Pg. 187-99, xii-xiii
(Feb 2012)
ISSN: 1558-1381 [Electronic] United States |
PMID | 22239883
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Plant Extracts
- TOR Serine-Threonine Kinases
- Leucine
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Topics |
- Animals
- Camellia sinensis
- Dietary Supplements
- Humans
- Leucine
(therapeutic use)
- Motor Activity
- Muscular Dystrophy, Duchenne
(drug therapy, physiopathology)
- Phytotherapy
- Plant Extracts
(therapeutic use)
- Signal Transduction
- TOR Serine-Threonine Kinases
(metabolism)
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