HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Uveodermatologic lymphoma in two young related Portuguese water dogs.

AbstractPURPOSE:
Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non-Hodgkin's and Hodgkin's lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed.
METHODS:
A 1-year-old female intact Portuguese water dog was referred to the Ophthalmology Service of the Veterinary Teaching Hospital of the Autonomous University of Barcelona because of acute blepharospasm of the right eye in association with a multinodular dermatosis. Physical and ophthalmological examination and a complete diagnostic work-up, including skin and ocular histopathology and immunohistochemistry, were performed. Three months prior, in Galicia (Spain), 1200 km away from Barcelona, a male dog of the same litter showed very similar oculodermatological clinical signs and skin histopathology, and immunohistochemistry were obtained.
RESULTS:
The clinical diagnoses were anterior exudative uveitis, iridal masses, and secondary glaucoma. Histopathology and immunohistochemistry revealed a nonepitheliotropic lymphoma rich in B cell in dog 1 and rich in T cell in dog 2.
CONCLUSION:
It is proposed that an underlying genetic predisposition could have played a role in the development of lymphoma in these two young related dogs.
AuthorsNatàlia Escanilla, Marta Leiva, Laura Ordeix, Teresa Peña
JournalVeterinary ophthalmology (Vet Ophthalmol) Vol. 15 Issue 5 Pg. 345-50 (Sep 2012) ISSN: 1463-5224 [Electronic] England
PMID22239173 (Publication Type: Case Reports, Journal Article)
Copyright© 2012 American College of Veterinary Ophthalmologists.
Topics
  • Animals
  • Dog Diseases (genetics, pathology)
  • Dogs
  • Female
  • Genetic Predisposition to Disease
  • Lymphoma (genetics, pathology, veterinary)
  • Male
  • Skin Neoplasms (genetics, pathology, veterinary)
  • Uveal Neoplasms (genetics, pathology, veterinary)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: