Abstract |
The assumption that anesthesia has no serious, long-term, adverse central nervous system consequences may be true for most patients between 6 months and 60 years of age. However, for patients younger than 6 months or older than 60 years, that status quo assumption is under challenge from a growing body of evidence. Fetuses and newborns appear to be at risk because systems that would enable them to fully recover from the effects of more than 2 hours of anesthesia are still in development. In distinction, the elderly appear to be at risk because systems that once enabled them to fully recover have ever-diminishing capacity. Even for those between the age of 6 months and 60 years, full recovery may require replacing apoptosed neurons and pruning overabundant dendritic spines…perhaps leaving patients not quite the same person that they were before they were anesthetized.
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Authors | James E Cottrell, John Hartung |
Journal | The Mount Sinai journal of medicine, New York
(Mt Sinai J Med)
2012 Jan-Feb
Vol. 79
Issue 1
Pg. 75-94
ISSN: 1931-7581 [Electronic] United States |
PMID | 22238041
(Publication Type: Journal Article, Review)
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Copyright | © 2012 Mount Sinai School of Medicine. |
Topics |
- Age Factors
- Anesthesia
(adverse effects)
- Animals
- Cognition Disorders
(epidemiology, etiology)
- Developmental Disabilities
(epidemiology, etiology)
- Humans
- Incidence
- Postoperative Complications
- Surgical Procedures, Operative
(adverse effects)
- Time Factors
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